Recently I noticed a lot of pharma spam showing up in the comments on my own game site. Rather than try to delete the spam faster than it comes in, I've done two things.
- Connections engaging Bad Behavior are being rejected. This seems to be catching the bulk of the miscreants.
- Discussion posts are now checked against the StopForumSpam database. This is stopping comparatively few spammers, but it's a nice secondary defense for anything that gets past the Bad Behavior filter.
You can see how the filters are performing for your site by going into the Admin menu and selecting the Bad Behavior Statistics from the bottom of the screen.